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C-erbB-2 (HER 2/neu) TISSUE ASSAY
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| Fresh, frozen, paraffin-embedded or buffered formalin tissue.
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| c-erb B-2 (HER 2/neu) is an oncogene encoding a protein (MW 185,000) that shows major homology with epidermal growth factor receptor (EGFR). Studies performed using antibodies to HER 2/neu and EGFR yield similar results.
Over-expression and amplification of the HER 2/neu oncogene may be detected by positive immunohistochemical membranous staining and are associated with poorer prognosis. Absence of staining is considered a favorable prognostic indicator. Results of staining for EGFR have a similar significance.
This assay uses a commercial kit or one (or more) reagents(s) designated as "research use only" or "investigational use only" by the manufacturer. Test reliability has been validated by in-house evaluation.
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| ICD-9 (Dx) CODE INFORMATION |
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