CKR-5 GENE MUTATION ANALYSIS
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Polymerase Chain Reaction and Agarose Gel Electrophoresis
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One lavender (EDTA) or one yellow (ACD)
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5 mL anticoagulated whole blood at ambient temperature (Min: 3 mL whole blood)
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No deletions detected in the CKR-5 gene coding region. Profile includes: Appearance, Cholesterol, Triglyceride, Chylomicrons, VLDL, HDL, LDL.
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CKR-5 has been recently described in the literature as a monocyte cell surface protein with the capacity to act as a co-receptor for HIV-1. A specific 32 base pair deletion in the gene encoding CKR-5 has been demonstrated in 0.1% of Caucasians and 0.2% of African Americans surveyed. Proported resistance to HIV infection has been suggested in association with the homozygous phenotype. Individuals who are heterozygous for the deletion may posses resistance to a lesser degree or may demonstrate a long-term non-progressive course of disease. Additional investigations are ongoing to more extensivelydefine the cinical impact of CKR-5 modifications. Results should be interpreted accordingly in conjunction with clinical observations and the results of other established diagnostic procedures.
See report for list of references.
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| ICD-9 (Dx) CODE INFORMATION |
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