EPIDERMAL (SKIN) ANTIBODIES
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Indirect Fluorescent Antibody
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1 mL refrigerated serum (Min: 0.1 mL)
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Refrigerated - 1 week
Frozen - 6 months
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Samples with high degree or hemolysis, lipemia or microbial growth.
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Separate serum from cells ASAP.
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Anti-ICS: Negative
Anti-BM: Negative
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The epidermal Antibodies test will detect and differentiate between antibodies to intracellular substance (anti-ICS) and antibodies to basement membrane (anti-BM). Antibodies to the intracellular substance (ICS) of the epidermis is detectable in 90% of cases of Pemphigus, while antibodies to the basement membrane (BM) of the epidermis is found in 70% of Bullous Pemphigus cases. Patient's with Lydel's toxic neurolysis, extensive burns and myasthenia gravi may also demonstrate antibodies to intracellular substance.
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| ICD-9 (Dx) CODE INFORMATION |
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